Mapping genes for quantitative traits using linkage disequilibrium
نویسندگان
چکیده
منابع مشابه
Multi-loci Linkage Disequilibrium Mapping of Complex Traits
In genetics, linkage disequilibrium (LD) is a phenomenon arising from the co-inheritance of alleles at nearby loci on the same chromosome, i.e., the alleles at multiple tightly linked genetic loci pass nonrandomly from generation to generation in a natural population. Capitalizing on this phenomenon, a group of mapping methods, called LD mapping, have been developed recently for genetic associa...
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The advent of complete genetic linkage maps consisting of codominant DNA markers [typically restriction fragment length polymorphisms (RFLPs)] has stimulated interest in the systematic genetic dissection of discrete Mendelian factors underlying quantitative traits in experimental organisms. We describe here a set of analytical methods that modify and extend the classical theory for mapping such...
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1. Abstract 2. Introduction 3. Models and methods 3.1. Haplotype block characterization 3.2. Measure of haplotype block LD 3.3. Test statistic and power calculation 3.4. Population genetic model of haplotype block 4. Results 4.1. Haplotype block LD measure 4.2. Power of the haplotype block LD mapping 4.3. Mapping 5. Discussion 6. Appendix 6.1. Appendix A 6.2. Appendix B 6.3. Appendix C 7. Refer...
متن کاملMapping quantitative trait loci in a wild population using linkage and linkage disequilibrium analyses.
Historical information can be used, in addition to pedigree, traits and genotypes, to map quantitative trait locus (QTL) in general populations via maximum likelihood estimation of variance components. This analysis is known as linkage disequilibrium (LD) and linkage mapping, because it exploits both linkage in families and LD at the population level. The search for QTL in the wild population o...
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A novel and robust method for the fine-scale mapping of genes affecting complex traits, which combines linkage and linkage-disequilibrium information, is proposed. Linkage information refers to recombinations within the marker-genotyped generations and linkage disequilibrium to historical recombinations before genotyping started. The identity-by-descent (IBD) probabilities at the quantitative t...
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ژورنال
عنوان ژورنال: Genetics Selection Evolution
سال: 1991
ISSN: 0754-0264
DOI: 10.1051/gse:19910721